Figure 2. Histological features of Case 1.

Histologically, Case 1 reveals a neoplasia composed of large- and medium-sized cells with an elongated appearance in a hemorrhagic stroma (H&E x200) (A). (H&E x400) (B) These cells exhibit cellular atypia and mitotic figures (blue arrow), (C) dense eosinophilic cytoplasm with signet ring cell appearance and nuclei pushed to the periphery (blue arrow), and (D,E) elongated or spindle-shaped cells with double nuclei (blue arrows), (F) and lymphocytic infiltrate (blue arrow). Areas also show alterations in intercellular junctions, fine vacuoles, and dense granules of varying sizes and shapes.