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Immunohistochemistry features reveal loss of S-100 expression in both cases (A, B), loss of brachyury expression with granular appearance (C, D), loss of membranal EMA with granular intracytoplasmic appearance (E, F), focal and patchy CDK4 positivity, and cytoplasmic p53 expression in each case (G) (IHQ stain, original magnification x400).
