This figure shows high-risk cluster locations and radii for disease and year for the unadjusted analysis (left), and high-risk cluster locations and radii for disease and year for the poverty-adjusted analysis (right). The shapefile used was from the US Census Bureau publicly available TIGER/Line Shapefiles. Counties at the center of high-risk clusters in consecutive years (see S4 File) were found for COVID-19, HIV, and Influenza. Central counties for high-risk clusters for COVID-19 were in Miami-Dade County, FL, New York County, NY, Westmoreland County, PA and Yuma County, AZ. Counties at the center of regions with high disease burden of HIV in consecutive years were Anne Arundel County, MD, Lake County, FL, Los Angeles County, CA and San Francisco County, CA. The county with a high disease burden of influenza in consecutive years was Boone County, MO. Based on this analysis, none of the counties were at the center of high-risk clusters for TB in consecutive years.