Krittayaphong 2003.

Methods	Randomised controlled trial.
Participants	Included patients with: (1) 15‐75 years old; (2) symptomatic paroxysmal or persistent AF for more than 6 months; (3) refractory to at least 1 antiarrhythmic medication including class IA or IC agents, digitalis, beta‐blocker, or calcium channel blocker; (4) never been given amiodarone. 30 patients were enrolled. 15 patients were assigned to PVI and linear ablation of right atrium group, and 15 to medicine group. Age: 48.6+/‐15.4 years in amiodarone group, and 55.3+/‐10.5 years in RFCA group. % of male: 8/15 (53.3%) in amiodarone group, and 11/15 (73.3%) in RFCA group. Follow‐up: 12 months. Location: Bangkok, Thailand.
Interventions	Catheter ablation group: Pulmonary vein isolation and linear ablation of right atrium. Medicine group: amiodarone (1200mg per day for 1 week, 600mg per day for another 2 weeks, and the maintenance dose was 200mg per day).
Outcomes	Effects of treatment on symptoms and quality of life, effects of treatment on cardiac rhythm, adverse effects.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient detail was provided.
Allocation concealment (selection bias)	Unclear risk	B‐Unclear. The authors did not depict allocation concealment method.
Blinding	High risk	Blinding was not reported.
Incomplete outcome data addressed	High risk	There were no patients withdrawn or lost to follow up.
Adequate sequence generation	Unclear risk	It was not addressed.