Figure 3. Diverse roles of mitochondrial phospholipids regulating OXPHOS.

The effects of IMM lipids on bioenergetics are likely mediated by lipid-to-protein interactions that affect OXPHOS enzyme activity, membrane properties that influence lateral diffusability of electron carriers through IMM and proton conductance across the IMM, by influencing the interaction of respiratory complexes to facilitate efficient electron transfer and regulate electron leak, and cristae architecture that regulates compartmentalization of mitochondrial membrane potential.