Extended Data Fig. 7. Validation of CRPS for colorectal tumour classification.

a, Comparison of CRPS to iCMS in this cohort. b-c, In total, eleven external CRC datasets (n = 2,832 samples) from NCBI GEO and NCI Genomic Data Commons were uniformly processed and transformed to pathway profiles with ssGSEA. Comparison of CRPS, CMS and iCMS classification for all external datasets (b) and the TCGA COAD/READ dataset only (c). The samples were coloured after their CMS subtype. d, Overall survival shown by CRPS, CMS and iCMS subgroups for external datasets, calculated with Kaplan-Meier curves and log-rank test. Adjusted HR (aHR) and P (aP) values or HR and P values were calculated by multivariable Cox with or without adjustment for tumour stage. e, Comparison of CMS Gene-Set activities using CMScaller (version: v0.9.2) for the TCGA dataset (left) and this cohort (right) displayed by CRPS subgroup (columns). Upregulation marked in red and downregulation in blue for each activity by row. NA, undefined subtype.