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. 2024 Aug 7;633(8028):137–146. doi: 10.1038/s41586-024-07769-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — Hypoxia scores based on the Buffa mRNA abundance signature were calculated for all tumours (top) and correlated with (a) mutations in the 96 driver genes, (b) mutation burden and somatic structural variants, and (c) numbers of mutations attributed as clonal and subclonal. Adjusted FDR P-values shown to the right and significance threshold indicated by dotted line (F-test full and null models’ comparison, FDR < 0.05). PGA, percentage of genome with copy number alterations; CNA, copy number alterations; SNV, single nucleotide variation; DNV, double nucleotide variation; TNV, triple nucleotide variation; DEL, deletion; INS, insertion; INDEL, insertion and deletion.