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. 2024 Aug 7;633(8028):137–146. doi: 10.1038/s41586-024-07769-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 10 — a, Overall and recurrence free survival displayed by mismatch repair status and MSI class for cells predicted by CIBERSORT (left) and xCell (right) algorithms. Univariable Cox regression was performed on cell types that showed expression in at least 5 patients with survival data, and statistically significant differences (* P < 0.05, ** P < 0.01, and *** P < 0.001) were further tested by multivariable Cox regression with co-variates including tumour site, treatment status, tumour stage, age groups, and tumour grade. The hazard ratio values are indicated by colour intensity. b, Percentage of tumours with somatic mutations in 96 driver genes for MSI class 1 (top) and class 2 (bottom) cases. c, Percentage of tumours with somatic copy number variation of 96 driver genes for MSI class 1 (top) and class 2 (bottom) cases. d, Percentage of tumours with focal copy number regions (Q < 0.1) gained or lost, determined by GISTIC in the MSI class 1 (top) and class 2 (bottom) cases. LOH, loss of heterozygosity; cn, copy number neutral; AMP, amplification; HOMDEL, homozygous deletion; HETLOSS, heterozygous deletion.