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. 2024 Sep 4;15:7731. doi: 10.1038/s41467-024-51577-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Comparison of count and class of driver gene mutations in the Oxford Cohort (n = 51) (supporting data Table S11). Concordance in calling of B actionable variants (supporting data Table S12) and C mutational signatures between FFPE and FF specimen in the Oxford Cohort. Dotted line represents 100% concordance (R = 1), and the colour of the points demonstrates the proportion of FFPE calls that are complementary to the matched FF specimen. A log-scale is used for mutational signatures. D Heatmap comparing genomic characteristics in the PARTNER/PBCP Cohort (n = 14). The top 20 mutated Domain 1 genes are presented. Common breast signatures are presented for substitution and rearrangement, whilst only indel signatures with proposed aetiology are presented. HRDetect is again calculated following correction for indel artefact as discussed in the “Methods” section and supplementary information. Cancer cell content (CCC) is provided for both FF and FFPE samples. Correlation was assessed using Spearman’s Rank Correlation. FF fresh frozen, FFPE formalin fixed paraffin embedded.