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. 2024 Sep 4;14:357. doi: 10.1038/s41398-024-03074-9

Fig. 2. Size of the penalized regression coefficients and rank of importance of the predictor variables in the least absolute shrinkage and selection operator (LASSO) models.

Fig. 2

As one LASSO model was developed for each response variable, each column in the tile plot displays the results of one LASSO model. The rank of relative importance of each predictor for each outcome was determined by ranking the predictor variables according to their absolute size of the regression coefficients in each LASSO model. The data used are the difference between the LSD and the respective placebo session. The peak effect was used for the physiological effects. CYP cytochrome P450, MRI magnetic resonance imaging, VAS visual analog scale (area under the effect-time curve 0–11.5 h), AMRS adjective mood rating scale, NEO-FFI NEO five-factor inventory, 5D-ASC five dimensional altered states of consciousness, MEQ30 30-item mystical effects questionnaire, AUC area under the curve from 0–∞ h.