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. 2024 Sep 4;15:7719. doi: 10.1038/s41467-024-51934-1

Fig. 4. MenA1 abolishes MenT1 nucleotide specificity.

Fig. 4

a–d Thermal shift isotherms of MenT1 incubated with MgCl2 in the absence and presence of either ATP (a), CTP (b), GTP (c), or UTP (d). Isotherms are normalized between minima and maxima for presentation and comparison, cropped to the appropriate scale. e, f Mean changes in melting temperature following overnight incubation of MenT1 with MgCl2 and either ATP, CTP, GTP, or UTP, in the absence (e) and presence (f) of MenA1 (one-way ANOVA; (e) *** p = 0.0004; (f) p = 0.323). Plotted data represent the mean +/- SEM (3 replicates). Source data are provided as a Source Data file.