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. 2024 Sep 4;15:7710. doi: 10.1038/s41467-024-51948-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — a Superimposition of inward state of MtEfpA (lightgray-gray-darkgray), predicted by AlphaFold, with outward state of MtEfpA (blue-lightblue-lightpink). b Movement of MtEfpA’s NTD and hinge domain from an inward state to an outward state. c The PE binding cavity at site C in outward state (right) is blocked by TM2a moving near TM13 in inward state (left). d The binding cavity at site B changes from inward open (left) to outward open (right). e The tunnel in inward and outward states of MtEfpA.