Table 3.
Adjusted Cox Spline Models for Diastolic Blood Pressure
| Women with a History of Breast Cancer (n = 12,713) |
Matched Controls (n = 55,886) |
|||
|---|---|---|---|---|
| Events | HR (95% CI) | Events | HR (95% CI) | |
| Ischemic heart disease | 628 | 1.10 (0.98-1.24) | 3,129 | 1.07 (1.02-1.13) |
| Stroke | 401 | 1.91 (1.68-2.18) | 1,838 | 1.58 (1.48-1.68) |
| HF/cardiomyopathy | 848 | 1.09 (0.99-1.21) | 3,324 | 1.02 (0.97-1.07) |
| Any Primary CVD | 1,541 | 1.25 (1.16-1.34) | 6,809 | 1.17 (1.13-1.21) |
| Ischemic heart disease (mm Hg) | ||||
| <60 | 35 | 1.53 (1.07-2.19) | 190 | 1.31 (1.12-1.53) |
| 60-69 | 214 | Reference | 1,199 | Reference |
| 70-79 | 300 | 1.12 (0.94-1.34) | 1,403 | 0.99 (0.92-1.08) |
| 80-90 | 72 | 1.50 (1.14-1.98) | 309 | 1.25 (1.10-1.42) |
| Stroke (mm Hg) | ||||
| <60 | 19 | 1.37 (0.85-2.22) | 75 | 0.89 (0.70-1.13) |
| 60-69 | 128 | Reference | 648 | Reference |
| 70-79 | 184 | 1.27 (1.01-1.60) | 842 | 0.89 (0.70-1.13) |
| 80-90 | 57 | 2.56 (1.85-3.55) | 241 | 2.27 (1.95-2.64) |
| HF/cardiomyopathy (mm Hg) | ||||
| <60 | 43 | 1.34 (0.97-1.85) | 214 | 1.32 (1.14-1.53) |
| 60-69 | 331 | 1.08 (0.93-1.26) | 1,412 | 1.09 (1.01-1.17) |
| 70-79 | 373 | Reference | 1,382 | Reference |
| 80-90 | 93 | 1.54 (1.22-1.94) | 289 | 1.32 (1.16-1.50) |
| Any primary CVD (mm Hg) | ||||
| <60 | 75 | 1.28 (1.00-1.63) | 374 | 1.13 (1.01-1.26) |
| 60-69 | 561 | 0.97 (0.87-1.09) | 2,640 | 0.97 (0.92-1.02) |
| 70-79 | 699 | Reference | 3,027 | Reference |
| 80-90 | 185 | 0.97 (0.87-1.09) | 704 | 1.43 (1.32-1.55) |
CVD = cardiovascular disease; HF = heart failure.
Adjusted model: Age, race, BMI, smoking status, diabetes, and dyslipidemia.