Figure 3.

Mutational landscape of NSCLC patients. (A) Oncoplot of the top 10 most frequently-mutated genes and relevant mutations from the literature and current analysis. Patient columns are stratified by presence versus absence of AXL+ infiltrating immune cells. (B) Boxplot of non-synonymous tumor mutational burden (TMB, mutations per megabase) in AXL IC-negative versus -positive patients. (C) Enrichment plot of gene mutations that occur significantly more frequently (X² p<0.05) in PDL1 TPS-high, AXL Hscore-high (Hscore >50) or double-positive patient groups.