Figure 4.

The epigenome–metabolism nexus in retinal aging. Among the signatures of retinal aging, epigenome–metabolism crosstalk is now emerging as a key determinant of age-related molecular and functional changes. Traditionally, genomic and epigenomic alterations have been considered primary drivers of aging. However, aging-related metabolic dysregulation and the possibility of epigenome moderation through metabolites are suggestive of a previously unappreciated molecular nexus. Asterisks indicate advanced glycation end product–modified biomolecules.