Summary of findings for the main comparison. Brief co‐incubation compared to standard insemination for in vitro fertilization techniques.
| Brief co‐incubation compared to standard insemination for in vitro fertilization techniques | ||||||
| Patient or population: patients with in vitro fertilization techniques Settings: Intervention: Brief co‐incubation Comparison: standard insemination | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of Participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| Standard insemination | Brief co‐incubation | |||||
| Ongoing pregnancy per randomized woman | 213 per 1000 | 396 per 1000 (296 to 505) | OR 2.42 (1.55 to 3.77) | 426 (2 studies) | ⊕⊕⊝⊝ low1 | |
| Clinical pregnancy rate per randomized woman | 177 per 1000 | 337 per 1000 (238 to 453) | OR 2.36 (1.45 to 3.85) | 372 (3 studies) | ⊕⊕⊝⊝ low2 | |
| Miscarriage rate per randomized woman | 24 per 1000 | 47 per 1000 (9 to 217) | OR 1.98 (0.35 to 11.09) | 167 (1 study) | ⊕⊕⊝⊝ low3 | |
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; OR: Odds ratio; | ||||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
1 One trial lacked adequate explanation for methods of randomization. Allocation concealment not mentioned in any trial. 2 Two trials lacked adequate explanation for randomization methods. Allocation concealment not mentioned in any trial. 3 One trial only and no method of randomization or allocation concealment stated.