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. Author manuscript; available in PMC: 2024 Sep 5.
Published in final edited form as: Cytotherapy. 2020 Dec 7;23(2):119–130. doi: 10.1016/j.jcyt.2020.11.002

Fig. 7. Approach to targeting C. neoformans with CAR+ T cells.

Fig. 7.

Schematic shows that T cells engineered to express GXMR-CAR via lentiviral transduction can target C. neoformans. In vitro and in vivo studies demonstrated that GXMR-CAR+ T cells interact with C. neoformans yeast and that GXMR-CAR+ T cells infused in NSG mice infected with C. neoformans promoted a reduction in the number of titan cells in the lungs. We suggest that GXMR-CAR+ T cells use two major mechanisms to control cryptococcosis: 1) activation of neutrophils and APCs by proinflammatory mediators released by GXMR-CAR+ T cells and 2) production of granzyme, perforin, and granulysin by GXMR-CAR+ T cells acting on the C. neoformans.