Table 1.
Description of the study sample – sociodemographic and clinical characteristics
| Overall (n = 87) | Cerebral amyloid angiopathy (n = 69) | NC (n = 18) | p-value (p < 0.05) group analysis | p-value subgroup analysis* | |
|---|---|---|---|---|---|
| Age, y | 72.68 (7.36) | 72.99 (7.80) | 71.50 (5.34) | 0.372 | |
| Male, n (%) | 46 (52.9) | 38 (55.10) | 8 (44.40) | 0.421 | |
| Years of education | 13 (8–23) | 12.5 (8–23) | 15.5 (12–19) | 0.010 | |
| Diabetes mellitus, n (%) | 23 (26.4) | 19 (27.50) | 4 (22.20) | 0.770 | |
| Arterial hypertension, n (%) | 73 (83.9) | 63 (91.30) | 10 (55.60) | 0.001 | |
| Dyslipidemia, n (%) | 44 (50.6) | 37 (53.60) | 7 (38.90) | 0.265 | |
| Smoking, n (%) |
n = 84 24 (28.57) |
n = 66 20 (30.30) |
n = 18 4 (22.20) |
0.501 | |
|
APOE status APOEε3ε3 APOEε3ε2 or APOEε2ε2 APOEε3ε4 or APOEε4ε4 APOEε2ε4 |
n = 79 37 (46.83) 10 (12.65) 30 (37.97) 3 (3.79) |
n = 61 27 (44.26) 7 (11.47) 26 (42.62) 1 (1.63) |
n = 18 10 (55.6) 2 (11.10) 4 (22.20) 2 (11.10) |
0.143 |
p < 0.00625 0.398 0.965 0.117 0.064 |
|
Cognitive status Cognitively normal, n (%) Mild cognitive impairment, n (%) Mild dementia, n (%) Severe dementia, n (%) |
n = 85 43 (50.58) 30 (35.29) 12 (14.11) 0 (0) |
n = 67 25 (37.31) 30 (44.77) 12 (17.91) 0 (0) |
n = 18 18 (100) 0 (0) 0 (0) 0 (0) |
< 0.001 |
p < 0.0083 < 0.001 < 0.001 0.052 |
Note: Values are mean (standard deviation) or median (range) unless otherwise noted. Significant p-values are marked bold. p-values are based on chi-square or Fisher’s exact test (if any cell number was < 5) for categorical variables, and the Mann-Whitney U test for continuous variables. *p-value subgroup analysis is based on post-hoc chi-square testing for multiple comparisons. n: number. y: years. NC: Cognitively normal control. APOE: Apolipoprotein E