Table 2.

Description of the study sample – NPS and lifelong mental activities

	Overall (n = 87)	Cerebral amyloid angiopathy (n = 69)	NC (n = 18)	p-value (p < 0.05) group analysis	p-value subgroup analysis*
ADAS-NC
ADAS-NC9 total number	1 (0–6)	2 (0–6)	0 (0–1)	< 0.001
ADAS-NC9 total severity	2 (0–11)	3 (0–11)	0 (0–2)	< 0.001
GDS-SF No depression, n (%) Minor depressive disorder, n (%) Major depressive disorder, n (%)	n = 85 56 (65.88) 26 (30.58) 3 (3.52)	n = 67 38 (56.71) 26 (38.80) 3 (4.47)	n = 18 18 (100) 0 (0) 0 (0)	0.001	p < 0.0083 < 0.001 0.002 0.374
LEQ
LEQ YA education	16.50 (7.96)	15.68 (8.20)	19.64 (6.18)	0.009
LEQ YA activities	19.18 (3.93)	19.03 (3.84)	19.76 (4.34)	0.797
LEQ YA total	36.49 (10.10)	35.47 (10.42)	40.39 (7.87)	0.012
LEQ ML occupation	61.58 (22.75)	59.51 (22.79)	69.52 (21.34)	0.098
LEQ ML activities	16.78 (3.63)	16.43 (3.61)	18.11 (3.49)	0.047
LEQ ML total	34.34 (8.68)	32.90 (8.25)	39.84 (8.28)	0.003
LEQ LL specific activities	18.71 (5.00)	17.50 (4.59)	23.35 (3.72)	< 0.001
LEQ LL nonspecific activities	14.58 (3.03)	13.93 (2.80)	17.05 (2.64)	< 0.001
LEQ LL total	22.39 (5.32)	21.35 (5.20)	26.40 (3.71)	< 0.001
LEQ total (cognitive reserve)	93.02 (18.63)	89.47 (18.28)	106.63 (13.08)	< 0.001

Note: Values are mean (standard deviation) or median (range) unless otherwise noted. Significant p-values are marked bold. p-values are based on chi-square or Fisher’s exact test (if any cell number was < 5) for categorical variables, and the Mann-Whitney U test for continuous variables. *p-value subgroup analysis is based on post-hoc chi-square testing for multiple comparisons. NPS: neuropsychiatric symptoms. ADAS-NC9: Alzheimer’s Disease Assessment Scale subscale noncognitive with nine items. GDS-SF: Geriatric Depression Scale-Short Form. LEQ: Lifetime of Experiences Questionnaire. YA: young adult. ML: mid-life. LL: late-life