Table 4.

Multivariable-adjusted associations of CAA diagnosis with the number and severity of NPS.

	Number of NPS		NPS total severity
	Incidence rate ratio (95% CI)	p-value	Estimate (95% CI)	p-value
Step 1
CAA diagnosis Age Female Years of education	6.07 (3.15 to 11.69) 1.05 (1.01 to 1.09) 1.31 (0.76 to 2.26) 0.98 (0.89 to 1.08)	< 0.001 0.009 0.324 0.738	3.32 (1.86 to 4.79) 0.10 (0.02 to 0.18) 0.56 (-0.64 to 1.78) -0.01 (-0.22 to 0.19)	< 0.001 0.015 0.355 0.913
Step 2
CAA diagnosis Age Female Years of education Arterial hypertension	6.03 (2.99 to 12.19) 1.05 (1.01 to 1.09) 1.31 (0.76 to 2.26) 0.98 (0.89 to 1.08) 1.01 (0.47 to 2.18)	< 0.001 0.009 0.323 0.743 0.964	3.36 (1.78 to 4.94) 0.10 (0.02 to 0.18) 0.56 (-0.66 to 1.78) -0.01 (-0.22 to 0.19) -0.11 (-1.83 to 1.61)	< 0.001 0.016 0.366 0.902 0.898
Step 3
CAA diagnosis Age Female Years of education Arterial hypertension AD pathology	4.43 (1.97 to 9.94) 1.05 (1.01 to 1.09) 1.28 (0.74 to 2.20) 0.98 (0.89 to 1.07) 1.09 (0.51 to 2.34) 1.15 (0.50 to 2.64)	< 0.001 0.009 0.366 0.720 0.816 0.726	3.34 (1.75 to 4.92) 0.09 (0.01 to 0.18) 0.57 (-0.65 to 1.80) -0.01 (-0.22 to 0.19) -0.06 (-1.79 to 1.66) 0.74 (-1.13 to 2.62)	< 0.001 0.025 0.355 0.883 0.944 0.433
Step 4
CAA diagnosis Age Female Years of education Arterial hypertension AD pathology	4.86 (2.20 to 10.73) 1.05 (1.01 to 1.08) 1.26 (0.74 to 2.13) 0.98 (0.89 to 1.07) 1.08 (0.52 to 2.26) 1.50 (0.62 to 3.57)	< 0.001 0.009 0.380 0.746 0.823 0.360	3.56 (1.94 to 5.19) 0.09 (0.00 to 0.18) 0.58 (-0.65 to 1.82) 0.00 (-0.22 to 0.21) -0.08 (-1.81 to 1.65) 1.10 (-0.92 to 3.13)	< 0.001 0.031 0.349 0.972 0.927 0.281
APOE status
Ho/he APOEε4 Ho/he APOEε2 APOEε4 and APOEε2	0.48 (0.26 to 0.90) 0.51 (0.22 to 1.22) 1.52 (0.36 to 6.30)	0.022 0.135 0.562	-0.90 (-2.45 to 0.63) -1.01 (-3.17 to 1.13) 0.41 (-3.01 to 3.85)	0.247 0.350 0.809

Note: CI: confidence interval. AD: Alzheimer’s disease. Ho/he: homozygote or heterozygote. Significant p-values are marked bold