Table 5.

Multivariable-adjusted associations of imaging markers of CAA severity with the number and severity of NPS.

	Number of NPS		NPS total severity
	Incidence rate ratio (95% CI)	p-value	Estimate (95% CI)	p-value
Marker
CSO PVS (category 0–4) WMH sum (category 0–6) Lobar CMB count CSS sum (category 0–4) CAA score (0–6)	1.12 (0.84 to 1.49) 1.21 (1.05 to 1.39) 1.00 (0.99 to 1.00) 1.02 (0.88 to 1.20) 1.14 (1.01 to 1.27)	0.426 0.006 0.954 0.719 0.022	0.13 (-0.84 to 1.10) 0.63 (0.19 to 1.08) 0.00 (-0.12 to 0.02) 0.28 (-0.35 to 0.92) 0.57 (0.19 to 0.95)	0.791 0.005 0.473 0.373 0.004

Note: Covariates were age, sex, years of education, arterial hypertension, AD pathology, APOE status, and magnetic resonance imaging field strength (3 Tesla or 1.5 Tesla). Significant p-values are marked bold. CSO PVS: centrum semiovale enlarged perivascular spaces. WMH: white matter hyperintensities. CMB: cerebral microbleeds. CSS: cortical superficial siderosis