Table 4.

Depression mediating the association between epilepsy and sleep disturbance

	ACME				ADE				Total effect				Proportion mediated
	Estimate	95%CI lower	95%CI upper	P-value	Estimate	95%CI lower	95%CI upper	P-value	Estimate	95%CI lower	95%CI upper	P-value	Estimate	95%CI lower	95%CI upper	P-value
Model 1	0.053	0.007	0.020	<0.001	0.147	0.066	0.228	<0.001	0.200	0.117	0.284	<0.001	0.265	0.117	0.648	<0.001
Model 2	0.049	0.006	0.020	<0.001	0.144	0.063	0.224	<0.001	0.193	0.109	0.277	<0.001	0.254	0.112	0.395	<0.001
Model 3	0.037	0.004	0.015	<0.001	0.124	0.044	0.204	0.002	0.161	0.078	0.243	<0.001	0.230	0.071	0.379	<0.001

Model 1: No covariate were adjusted. Model 2: Adjusted for age, sex, race, education, marital status and PIR. Model 3: Adjusted for age, sex, race, education, marital status, PIR, smoking status, diabetes, hypertension, CHD, asthma. Abbreviations: ACME, average causal mediation effect; ADE, average direct effect