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. Author manuscript; available in PMC: 2024 Sep 5.
Published in final edited form as: Nat Microbiol. 2023 Jan 23;8(3):548–561. doi: 10.1038/s41564-022-01313-7

Extended Data Fig. 8 |. Transcriptional effects of a PknL and PknK kinase-dead mutant.

Extended Data Fig. 8 |

(a) The PknL kinase-dead mutant reduces the DEGs compared to WT OE from 260 to 1. PknL WT and kinase-dead transcripts are highlighted in green, showing induction in both cases. (b) The PknK kinase-dead mutant reduces DEGs compared to WT OE from 181 to 13, suggesting a small transcriptional effect of the PknK malT domain in the OE. PknK WT and kinase-dead transcripts are highlighted in green, showing induction in both cases. Horizontal and vertical red lines show significance cutoffs (>4-fold, P < 0.01) used for further analysis of DEGs. Significance was determined by calculating the geometric mean of five DE tools.