Figure 2:

Collage of clinical data of the whole cohort. (A) Representative MRI of a pediatric patient with GC. Upper row: Fluid-attenuated inversion recovery (FLAIR): high signal as a sign of diffuse tumor infiltration primarily in the right occipital, parietal, and temporal lobe as well as involvement of the contralateral hemisphere with little mass effect. Lower row: contrast-enhanced T1-weighted images: the occipital part of the tumor shows typical mild multifocal enhancement. (B) Histopathological features of GC. Microscopical examination of three representative GC tumors according to histopathological grading: the left side shows HE staining and the right Ki-67 immunohistochemistry of the respective case: GC_74, WHO grade II; GC_51, WHO grade III; GC_35, WHO grade IV. With higher WHO grade, increasing cellularity and proliferative activity can be detected. Scale bar equate to 100 µm in each case. (C) Composition of the treatment groups according to the WHO grade. ¹PFS and OS given as median and the interquartile range in parentheses. ^†Three cases were excluded for this analysis due to absent WHO grading. ^‡These patients did not receive an upfront cytotoxic treatment. (D) Kaplan–Meier plot including p-value of the (left) PFS and (right) OS in months according to WHO grading.