Figure 5:

Whole-exome sequencing of pediatric GC. (A) Oncoprint representation of an integrated annotation of single-nucleotide variants and DNA copy-number changes for pediatric GC (n = 46). Samples are arranged in columns with genes labeled along rows. Clinicopathological and molecular annotations are provided as bars according to the included key. (B) Lollipop plot of specific variants identified in pediatric GC cases in EGFR (left) and BCOR (right), scaled by number and colored according to the key provided. Abbreviations: cysteine-rich domain (cysteine); receptor L-domain (receptor); growth factor receptor domain 4 (GFR); protein kinase domain (protein kinase); non-ankyrin-repeat domain (NARD); ankyrin repeat domain (ARD); PCGF1-binding domain (PCGF).