Figure 4.

Effects of twice-daily, 7-day treatment with oral tenapanor (0.5 mg/kg) on the excitability of colon-projecting neurons in the DRG of acetic acid-sensitized rats (n = 23–35 cells). The excitability of DiI-labeled DRG neurons were examined by resting membrane potential (A), rheobase (B), 2x-rheobase-evoked action potential (C), and response to capsaicin (D). The data are presented as means ± SE. In all four measurements, two-way ANOVA revealed significant differences (P < 0.05) in both main effects of model and treatment. #Significant difference from saline-vehicle group; *significant difference from AA-vehicle group. AA, acetic acid; ANOVA, analysis of variance; DRG, dorsal root ganglia.