Table 3.
Prognostic performance of lactate, D-dimer and the combination for mortality prognosis
| Parameters | Lactate | D-dimer | Lactate and D-dimer |
|---|---|---|---|
| Cut-off | 4.8 | 2.4 | 0.592 |
| ACC%, (95% CI) | 72.6 (72.2, 73.1) | 75.0 (74.6, 75.4) | 71.4 (71.0, 71.9) |
| Se%, (95% CI) | 75.5 (63.9, 87.1) | 71.7 (59.6, 83.8) | 66.0 (53.3, 78.8) |
| Sp%, (95% CI) | 67.7 (51.3, 84.2) | 80.6 (66.7, 94.6) | 80.6 (66.7, 94.6) |
| PPV%, (95% CI) | 80.0 (68.9, 91.1) | 86.4 (76.2, 96.5) | 85.4 (74.5, 96.2) |
| NPV%, (95% CI) | 61.8 (45.4, 78.1) | 62.5 (47.5, 77.5) | 58.1 (43.4, 72.9) |
| PLR (95% CI) | 2.34 (1.37, 3.99) | 3.7 (1.77, 7.75) | 3.4 (1.62, 7.18) |
| NLR (95% CI) | 0.36 (0.21, 0.61) | 0.4 (0.22, 0.55) | 0.4 (0.28, 0.64) |
Note: ACC= accuracy; Se = sensitivity; Sp = specificity; PPV = positive predictive value; NPV = negative predictive value; PLR = positive likelihood ratio; NLR = negative likelihood ratio; lactate and D-dimer combination variable: y′= (−1.252) + 0.192 × lactate + 0.111 × D-dimer, probability=1/(1+e−y′)