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. 2024 Aug 23;15:1429514. doi: 10.3389/fendo.2024.1429514

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Copyright © 2024 Wang, Xu, Chen, Ding, Liu, Hou, Wu, Men, Bao, He and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scatter plot of the MR analyses. (A): The influence of six DNAm phenotypes on the age of menopause; (B): The impact of age of menopause on six DNAm phenotypes. SNP, single nucleotide polymorphism; MR, Mendelian randomization; DNAm, DNA methylation; Hannum, DNA methylation Hannum age acceleration; IEAA, Intrinsic epigenetic age acceleration; Gran, DNA methylation-estimated granulocyte proportions; GrimAgeAccel, DNA methylation GrimAge acceleration; PhenoAgeAccel, DNA methylation PhenoAge acceleration; DNAmPAIadjAge, DNA methylation-estimated plasminogen activator inhibitor-1 levels.