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. 2024 Jan 4;31(2):275–282. doi: 10.1038/s41594-023-01147-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — The structures are sorted by their HO values from top left to bottom right. The top left structure shows the smallest HO value and has irregularly packed α-helices, whereas the bottom right one shows the highest HO value and has parallelly aligned α-helices. The five designed topologies are shown together by enclosed squares.

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