Table 3.

Prognostic performance of pupillometry thresholds and NSE

	Sample size, n (%)	FPR, % (95% CI)	Sensitivity, % (95% CI)	PPV, % (95% CI)	NPV, % (95% CI)
qPLR < 4%
t0	710 (100)	5 (3–7)	31 (25–36)	78 (70–86)	70 (68–71)
t24	677 (95)	0 (0–1)	26 (21–32)	97 (92–100)	71 (69–72)
t48	540 (76)	0 (0–1)	21 (16–26)	98 (93–100)	65 (64–67)
t72	298 (42)	0 (0–0)	8 (4–12)	100 (100–100)	43 (42–44)
NPi ≤ 2
t0	710 (100)	0 (0–0)	10 (6–13)	100 (100–100)	65 (64–66)
t24	682 (96)	0 (0–0)	12 (8–17)	100 (100–100)	67 (66–67)
t48	543 (76)	0 (0–0)	9 (5–13)	100 (100–100)	62 (61–63)
t72	301 (42)	0 (0–0)	9 (5–13)	100 (100–100)	43 (42–44)
NSE > 60 μg/L
48-h	625 (88)	2 (0–3)	39 (33–46)	95 (91–100)	70 (67–72)
48-h plasma NSE and pupillometry predicting outcome in unconscious patients, M < 3, at ≥ 72 h
NSE > 60 μg/L	187 (26)	0 (0–0)	42 (35–51)	100 (100–100)	76 (70–82)
NSE > 60 μg/L + qPLR < 4.0	187 (26)	0 (0–0)	55 (47–63)	100 (100–100)	73 (66–79)
NSE > 60 μg/L + NPi ≤ 2.0	187 (26)	0 (0–0)	50 (42–58)	100 (100–100)	74 (68–81)
48-h plasma NSE and pupillometry predicting outcome in unconscious patients, M < 3, at ≥ 72 h (with extracerebral causes of death excluded)
NSE > 60 μg/L	172 (24)	0 (0–0)	45 (37–53)	100 (100–100)	76 (69–82)
NSE > 60 μg/L + qPLR < 4.0	172 (24)	0 (0–0)	58 (50–67)	100 (100–100)	72 (65–79)
NSE > 60 μg/L + NPi ≤ 2.0	172 (24)	0 (0–0)	51 (43–60)	100 (100–100)	75 (68–82)

The prognostic probabilities of quantitative pupillometry thresholds, 48-h plasma neuron-specific enolase, and the combination in unconscious patients, M < 3, at ≥ 72 h, predicting unfavorable outcomes at follow-up

qPLR quantitatively assessed pupillary light reflex, NPi Neurological Pupil index, M Glasgow motor scale, FPR false-positive rate, PPV positive predictive value, NPV negative predictive value