Table 4.

Multivariable Cox regression analysis of vaccination effect on in-hospital mortality for older hospitalized COVID-19 patients

	n/N	HR (95%CI)	p-value
Crude
Vaccinated	81/327	0.65 (0.41–1.04)	0.071
Model 1
Vaccinated, age (per year), male sex, not living at home	72/315	0.35 (0.20–0.61)	<0.001
Model 2
Vaccinated, age (per year), male sex, not living at home, high respiratory rate1	70/305	0.34 (0.19–0.60)	<0.001
Model 3
Vaccinated, age (per year), male sex, not living at home, high respiratory rate1, high CFS2 and CCI (per point)	59/260	0.30 (0.16–0.56)	<0.001

n number of deceased patients, N total number of cases without missing values, CFS Clinical Frailty Scale, CCI Charlson Comorbidity index

¹Respiratory rate > 20/min, ²CFS ≥ 4

Missings: 12 living at home, 10 respiratory rate, 52 CFS