Table 5.

Multivariable Cox regression analysis of vaccination effect on in-hospital mortality for older frail¹ hospitalized COVID-19 patients

	n/N	HR (95%CI)	p-value
Crude
Vaccinated	46/176	0.55 (0.29–1.05)	0.071
Model 1
Vaccinated, age (per year), male sex, not living at home	44/173	0.32 (0.15–0.67)	0.003
Model 2
Vaccinated, age (per year), male sex, not living at home, high respiratory rate1	42/166	0.31 (0.14–0.66)	0.003
Model 3
Vaccinated, age (per year), male sex, not living at home, high respiratory rate1, high CFS2 and CCI (per point)	29/127	0.32 (0.13–0.79)	0.013

Missings: 12 living at home, 10 respiratory rate, 52 CFS

n number of deceased patients, N total number of cases without missing values, CFS Clinical Frailty Scale, CCI Charlson Comorbidity index

¹Respiratory rate > 20/min, ²CFS ≥ 4