Table 3.

Univariate analysis of patients with MMA with cognitive impairment

	No VCIND	VCIND	P value
Number of patients	68	34
Clinical characteristics
Men, n (%)	25 (37)	11 (32)	0.66
Age at diagnosis, mean (SD)	39.4 ± 20.4	39.5 ± 14	0.92
Age at first neuropsychological assessment, mean (SD)	42.8 ± 13.5	43.3 ± 12.2	0.77
Delay first symptom/diagnosis (day), median (IQ)	45 (1–653)	85.5 (0–431)	0.79
MMA disease, n (%)	41 (60)	23 (68)	0.47
Vascular event at diagnosis, n (%)	45 (66)	29 (85)	0.041*
TIA and ischemic strokes	36 (53)	23 (68)	0.57
Ischemic stroke	26 (38)	22 (65)	0.012*
All strokes	35 (51)	28 (82)	0.002*
Hypertension, n (%)	20 (29)	10 (29)	1.00
Smoking, n (%)	24 (35)	13 (38)	0.77
Dyslipidemia, n (%)	12 (18)	10 (29)	0.19
Radiological characteristics
Bilateral involvement, n (%)	41 (60)	22 (65)	0.67
Transdural involvement, n (%)	15 (22)	6 (18)	0.60
Vertebro-basilar involvement, n (%)	8 (12)	8 (24)	0.12
Presence of ischemic lesions on MRI, n (%)	45 (66)	30 (88)	0.017*
Presence of hemorrhagic lesions on MRI, n (%)	10 (15)	6 (18)	0.70