Table 7.

Basophil counts and odds ratios for endometriosis with adjustment for age groups, WHR groups in ENDOX (n = 496), and UK Biobank (n = 7868). Logistic regression models were used by modeling basophil count groups as continuous variables.

	Basophil counts			Ptrend
	≤0.01	0.01–0.04	>0.04
ENDOX
Controls (n = 173)
n (%)	65 (37.57)	43 (24.86)	65 (37.57)
Endometriosis
Any stage (n = 323)
n (%)	95 (29.4)	75 (23.2)	153 (47.4)
OR (95% CI)	Reference	1.20 (0.73–1.98)	1.65 (1.06–2.57)	0.025*
r-AFS stage I/II (n = 207)
n (%)	66 (31.9)	47 (22.7)	94 (45.4)
OR (95% CI)	Reference	1.16 (0.67–2.02)	1.57 (0.96–2.55)	0.069
r-AFS stage III/IV (n = 111)
n (%)	26 (23.4)	27 (24.3)	58 (52.3
OR (95% CI)	Reference	1.45 (0.72–2.91)	2.30 (1.25–4.22)	0.007*
UK Biobank
Controls (n = 6331)
n (%)	2306 (36.4)	2232 (35.3)	1793 (28.3)
Endometriosis
Overall (n = 1537)
n (%)	499 (32.5)	556 (36.3)	482 (31.4)
OR (95% CI)	Reference	1.14 (1.00–1.31)	1.26 (1.09–1.45)	0.001*
Self-reported (n = 716)
n (%)	223 (31.2)	271 (37.9)	222 (31.0)
OR (95% CI)	Reference	1.25 (1.04–1.51)	1.30 (1.07–1.58)	0.008*
Hospital records (n = 1152)
n (%)	387 (33.6)	414 (35.9)	351 (30.5)
OR (95% CI)	Reference	1.10 (0.94–1.28)	1.18 (1.01–1.38)	0.042*
Surgically confirmed (n = 1294)
n (%)	416 (32.2)	454 (35.1)	424 (32.8)
OR (95% CI)	Reference	1.12 (0.97–1.30)	1.33 (1.14–1.54)	<0.001*
Severe cases (n = 337)
n (%)	106 (31.5)	116 (34.4)	115 (34.1)
OR (95% CI)	Reference	1.12 (0.85–1.47)	1.41 (1.08–1.86)	0.013*

*P values <0.05 were considered as evidence of a significant difference between comparison groups; P values for trend were derived from ordinal logistic regression models.

ENDOX: Endometriosis at Oxford Study; OR, odds ratio; r-AFS, revised American Fertility Society classification.