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. 2024 Sep 6;43:253. doi: 10.1186/s13046-024-03177-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — HSF1 is upregulated in human intrahepatic cholangiocarcinoma preinvasive lesions and metastases. Upper panels: Representative immunohistochemistry of HSF1 protein in a preinvasive lesion (one biliary intraepithelial neoplasia or BilIN specimen is shown here). The lesion exhibits pronounced nuclear immunoreactivity for HSF1. CK19 staining was used as a biliary marker. Lower panels: an iCCA lymph node metastasis displaying pronounced HSF1 nuclear immunolabeling in the tumor metastasis (M) and scattered nuclear positiveness in the lymph node (LN) compartment. CK19 staining was used as a biliary marker. Original magnification: 100x; scale bar: 200 μm. Abbreviations: H&E, hematoxylin and eosin staining