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. 2024 Sep 5;29:118. doi: 10.1186/s11658-024-00627-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — In vivo experiments validate the inhibitory effect of hsa_circ_0000520/ Lin28a on bladder cancer metastasis. A Schematic representation of the construction of the nude mouse lung metastasis model (Image elements from Biorender). B In vivo bioluminescence imaging analysis of lung metastasis in mice from each group. C Statistical analysis of the differences in the number of lung metastatic tumors in each group of mice. D Lung tissue sections stained with hematoxylin and eosin (HE) to analyze the tumor status in mice from each group. E Schematic representation of the construction of the nude mouse orthotopic bladder cancer transplantation model (Image elements from Biorender). F In vivo bioluminescence imaging analysis of tumor growth and metastasis in mice from each group. G Statistical analysis of the number of mice with or without metastasis in each group. H Statistical analysis of the differences in the number of tumor metastases in each group of mice. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001