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. 2024 Sep 6;10(36):eadl6162. doi: 10.1126/sciadv.adl6162

Fig. 4. Nociceptors dampen recruitment of neutrophils, monocytes, and interstitial macrophages into airways during CRKP infection.

Fig. 4.

(A) Numbers of leukocyte subsets quantified in BALF of Trpv1DTA and control littermates at 24 hpi or of PBS treatment. (B to E) Representative flow cytometry plots and absolute total numbers of neutrophils (CD11b+ Ly6G+) (B), Ly6Chi and Ly6Clo monocytes (C), AMs (Siglec-F+CD11b−CD11c+ F4/80+) (D), and interstitial macrophages (IMs; CD11b+ F4/80+) (E) in BALF of Trpv1DTA and control mice over time after CRKP infection or PBS treatment. Data in (A) to (E) are the means ± SEM and involve Trpv1DTA mice (n = 4 per group for 0, 6, and 12 hours and n = 8 per group for 24 hours) and control littermates (n = 4 per group for 0, 6, 12 hours and n = 7 per group for 24 hours). Data were analyzed by two-way ANOVA of two-stage liner step-up procedure of Benjamini, Krieger, and Yekutieli posttests with the following significance levels: *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.