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. 2024 Sep 6;10(36):eadl6162. doi: 10.1126/sciadv.adl6162

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Copyright © 2024 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 9. — Lung-innervating nociceptor neurons suppress the recruitment of neutrophils and Ly6C^hi monocytes to the airspaces of lungs during CRKP lung infection. CRKP infection induces vagal TRPV1⁺ neurons for releasing CGRP, which in turn acts on its receptor on Ly6C^hi monocytes to dampen the ROS production. This leads to an increased CRKP survival in the lungs and enhanced dissemination of bacteria to vital organs. BioRender.com was used to create model.