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. 2024 Aug 16;107:105285. doi: 10.1016/j.ebiom.2024.105285

Fig. 3.

Fig. 3

Gene expression analysis of antidiabetic drug targets and osteoarthritis. The heatmap illustrates the association between the expression of drug target genes in the blood (from eQTLGen) and 12 osteoarthritis phenotypes, with serum HbA1c, glucose levels, and T2DM as outcomes to confirm the direction of the results. A red region indicates a positive association, a blue region indicates a negative association, and the ORs (95% CIs) are displayed if the results are significant and pass the HEIDI test. Asterisks denote the level of significance (∗P < 0.05, ∗∗P < 0.05/25 for multiple corrections). Abbreviations: OA, Osteoarthritis; SMR, summary-based Mendelian randomisation; HbA1c, Hemoglobin A1C; T2DM, Type 2 Diabetes Mellitus; THR, Total Hip Replacement; TKR, Total Knee Replacement; AGI, alpha glucosidase inhibitors; DPP4i, dipeptidyl peptidase-4 inhibitors; GLP-1RA, glucagon-like peptide-1 receptor agonists; SGLT2i, sodium-glucose cotransporter 2 inhibitors; TZDs, Thiazolidinediones.