Fig. 5.

Colocalisation results of antidiabetic drug gene expression and osteoarthritis. The heatmap depicts the two-trait colocalisation analysis of putative targets with 12 osteoarthritis phenotypes (left) and the multiple-trait colocalisation analysis with specific osteoarthritis phenotype groups (right), where darker blue shading and asterisks indicate stronger evidence of colocalisation. ∗∗indicates PPH₄ >0.8 in coloc analysis. ∗indicates 0.5 <PPH₄ <0.8 in coloc analysis. ††indicates PPA >0.5 in moloc analysis. †indicates PPA >0.3 in moloc analysis. Abbreviations: OA, Osteoarthritis; THR, Total Hip Replacement; TKR, Total Knee Replacement; AGI, alpha glucosidase inhibitors; DPP4i, dipeptidyl peptidase-4 inhibitors; GLP-1RA, glucagon-like peptide-1 receptor agonists; SGLT2i, sodium-glucose cotransporter 2 inhibitors; TZDs, Thiazolidinediones.