Table 5. Matrix effect and recovery of donepezil (DPZ) in rat plasma (n = 6).
Nominal concentration of DPZ (ng/mL) | Recovery (mean ± SD, %) |
Matrix effect | |
---|---|---|---|
Mean ± SD (%) | CV (%) | ||
0.5 | 102.99± 4.74 | 98.81 ± 9.90 | 10.01 |
1.5 | 98.46 ± 8.30 | 103.75 ± 6.31 | 6.08 |
500 | 104.71 ± 3.30 | 100.40 ± 3.64 | 3.63 |
1,000 | 106.79 ± 2.98 | 92.17 ± 2.44 | 2.64 |