Table 5. Mortality associated virulence genes and clinical profile of the patients with CoNS-related infections.
DM- diabetes mellitus, CKD- chronic kidney disease, CRBSI- catheter related blood stream infection, CAD- coronary artery disease, VAP- ventilator acquired pneumonia, MODS- multiorgan dysfunction syndrome, CVA- cerebrovascular accident, UGI bleed- upper gastrointestinal tract, DCLD- decompensated chronic liver disease, RTA-road traffic accident, UTI- urinary tract infection, HTN- hypertension, A- ampicillin, CD- clindamycin, E- erythromycin, CIP- ciprofloxacin, CXM- cefuroxime, G- gentamicin, LZ- linezolid, VA- vancomycin
| Specimen | Virulence genes | Diagnosis | MRCONS / MSCONS | Antibiotic susceptibility |
| Staphylococcus haemolyticus | ||||
| Blood | atlE, embp | CKD, sepsis, perianal abscess | MSCONS | CD,G,CX,VA,LZ |
| Blood | icaAB, atlE | Multiple myeloma, CKD, sepsis | MSCONS | A,E,VA,LZ,CX |
| Blood | None | Sepsis, HTN, VAP | MSCONS | CX,VA,LZ |
| Exudate | icaAB, aap | Traumatic ulcer, wound infection following RTA, DM, HTN | MSCONS | CIP,CX,G,VA,LZ |
| Urine | None | DM, CVA, seizure | MRCONS (SCCmec type I) | G,VA,LZ |
| Exudate | None | Cellulitis, right hip implant infection | MRCONS (SCCmec type I) | VA,LZ |
| Blood | None | Sepsis, CKD, HTN, DM, CVA | MRCONS (SCCmec type I) | CD,VA,LZ |
| Urine | None | CKD, MODS, DM | MRCONS (SCCmec type I) | G,VA,LZ |
| Blood | None | Cellulitis, Sepsis, CKD, MODS | MRCONS (SCCmec type I) | CD,VA,LZ |
| Blood | None | Sepsis, UGI bleed, DCLD, CKD | MRCONS (SCCmec type I) | VA,LZ |
| Blood | None | Sepsis, CAD, CKD | MRCONS (SCCmec type I) | G,VA,LZ |
| Exudate | None | DM, HTN, CAD, CKD | MRCONS (SCCmec type I) | VA,LZ |
| Urine | None | CVA, sepsis, DM | MRCONS (SCCmec type I) | CIP,G,VA,LZ |
| Blood | aap, fbe | Duodenal ulcer, sepsis, DM, HTN, CKD | MR CONS (SCCmec type I) | CIP,G,VA,LZ |
| Blood | None | DM, CKD, sepsis | MR CONS (SCCmec type I) | VA, LZ |
| Blood | None | Urosepsis, DM, HTN, CKD | MR CONS (SCCmec type I) | G, VA, LZ |
| Blood | None | CKD, HTN, Sepsis | MR CONS (SCCmec type I) | E, CD, CIP, VA, LZ |
| Staphylococcus epidermidis | ||||
| Blood | fbe, atlE, embp | DM, urosepsis, CKD | MSCONS | E,CD,CIP,G,CX,VA,LZ |
| Blood | atlE, embp | Sepsis, UTI, cellulitis, CKD | MSCONS | E,CD,CIP,G,CX,VA,LZ |
| Blood | icaAB, aap, fbe | CAD, DM, VAP, CKD, sepsis | MSCONS | A,E, CD, CIP, G, VA, LZ, CTX |
| Blood | None | CVA, HTN, Sepsis | MRCONS (SCCmec non typable) | CD, VA, LZ |
| Blood | None | MODS, sepsis, Pyelonephritis, CVA, DM | MRCONS (SCCmec type I) | CD,G,VA,LZ |
| Blood | icaAB, atlE, fbe, aap, embp | DM, CAD, VAP, sepsis | MRCONS (SCCmec type III) | VA,LZ |
| Blood | fbe, atlE, embp | DM, connective tissue disorder, sepsis | MR CONS (SCCmec type I) | E, CD, CIP, G, VA, LZ |
| Urine | None | DM, HTN, CKD, sepsis | MR CONS (SCCmec type I) | G, VA, LZ |
| Blood | None | DM | MR CONS (SCCmec type III) | CD, CIP, G, VA, LZ |
| Staphylococcus hominis | ||||
| Blood | None | Sepsis, DM | MSCONS | CX,VA,LZ |
| Exudate | None | Sepsis, CKD, | MSCONS | CD,CIP,CX,VA,LZ |
| Exudate | fbe | Chronic Osteomyelitis | MSCONS | CD,G,CX,VA,LZ |
| Blood | icaAB, aap, fbe | DM, HTN, sepsis | MSCONS | E,CD,CIP,G,VA,LZ CTX |
| Blood | atlE, embp | Abscess, DM, sepsis | MSCONS | E, CD, G, VA, LZ, CTX |
| Exudate | None | DM, HTN | MSCONS | A, E, CD, G, VA, LZ, CTX |
| Blood | None | Septic shock multiorgan failure, VAP | MRCONS (SCCmec type III) | CD,VA,LZ |
| Blood | icaAB, fbe, atlE | Sepsis, supraglottic carcinoma | MRCONS (SCCmec type I) | E,CD,CIP,G,VA,LZ |
| Blood | atlE, embp | DM, cellulitis, sepsis | MRCONS (SCCmec non- typable) | G, VA, LZ |
| Blood | None | DM, UTI, sepsis | MRCONS (SCCmec type I) | CD, CIP, E, CIP, G, VA, LZ |
| Staphylococcus cohnii | ||||
| Blood | None | CAD, MODS, DM, AKI, UTI, sepsis | MRCONS (SCCmec non-typable ) | CIP,G,CX,VA,LZ |
| Blood | None | Sepsis, CKD, VAP, myocardial infraction | MRCONS (SCCmec non-typable) | CIP,G,VA,LZ |
| Blood | aap | Sepsis, urosepsis, DM | MRCONS (SCCmec type III) | G,VA,LZ |
| Staphylococcus saprophyticus | ||||
| Blood | None | CAD, type 2 respiratory failure, bronchiectasis, sepsis | MRCONS (SCCmec type I) | G,CIP,VA,LZ |
| Staphylococcus arlattae | ||||
| Blood | None | Sepsis, CKD, DM, HTN, CAD | MSCONS | CIP, G, CTX, VA, LZ |
| Blood | None | DCLD, HTN, sepsis | MRCONS (SCCmec type I) | E, CD, CIP, G, VA, LZ |
| Staphylococcus capitis | ||||
| Blood | None | HTN, CKD, post renal transplant graft rejection, sepsis | MSCONS | A,E,CD,CIP,G,CX,VA,LZ |
| Staphylococcus sciuri | ||||
| Blood | None | Sepsis, CKD, CAD, DM, HTN | MSCONS | E, CD, CIP, CXM, G, VA, LZ, TEI |