Figure 2.

Enrichment of cases in the top percentiles of the cardiovascular disease polygenic risk score distribution. Bars represent the top 20% (blue), top 10% (purple), top 5% (orange), top 3% (pink) and top 1% (green) of the polygenic risk score distribution. Y-axis represents the proportion of major cardiovascular disease event cases captured in individuals at or above the stated polygenic risk score percentile. Yellow lines indicate no-enrichment values (% of cases matches % of polygenic risk score distribution)