Abstract
Medial collateral ligament (MCL) injuries are prevalent in sports and other physical activities and constitute a significant cause of knee pain and dysfunction. Traditional diagnostic modalities such as magnetic resonance imaging (MRI) are often utilized for their detailed visualization capabilities. However, musculoskeletal ultrasound (MSK-US) has emerged as a pivotal diagnostic tool in the evaluation of MCL injuries due to its non-invasive nature, cost-effectiveness, and dynamic imaging capabilities. This article reviews the utility and advantages of MSK-US in diagnosing MCL injuries, with a specific focus on its implications for rehabilitation providers. We discuss the technical aspects of ultrasound (US) imaging, including the sonographic appearance of MCL injuries across various grades, and compare its diagnostic accuracy with other imaging modalities such as MRI. Additionally, the role of US in monitoring the healing process and guiding rehabilitation strategies is explored. This review emphasizes the practical application of MSK-US in clinical settings, offering rehabilitation providers a comprehensive understanding of how US can be integrated into patient management protocols to enhance outcomes in patients with MCL injuries.
Keywords: Musculoskeletal Ultrasound, Medial Collateral Ligament, Knee Injuries, Diagnostic Imaging, Rehabilitation
Introduction
The medial collateral ligament (MCL) of the knee is frequently injured during sports and physical activities, resulting in various degrees of pain, swelling, and instability. Despite the fact that the MCL is one of the most commonly injured knee ligaments,1 literature on this structure is relatively poor.2 The MCL is a crucial stabilizer of the medial knee joint and is the most commonly injured knee ligament, typically due to direct blows or sudden directional changes during activity producing a valgus forces.3–6
The MCL complex consists of three structures: the superficial medial collateral ligament (sMCL) which is composed of anterior vertically oriented and posterior oblique oriented fibers, and the deep medial collateral ligament (dMCL) which is made of from a thickening of the medial joint capsule, the meniscofemoral and meniscotibial ligaments.7 Injuries to these components often result from combined valgus and external rotational forces on the tibia.5,8 Interestingly, even though the sMCL is farther from the joint axis of rotation of valgus stress, due to the relatively short length of the fibers of the dMCL, it may actually tear before the sMCL when the knee is subjected to a valgus stress.8,9 Most MCL injuries can be managed nonoperatively with good functional outcomes.6,10–12 However, reconstruction is indicated in cases of persistent grade 3 medial knee laxity.3,13,14 Untreated or inadequately treated medial knee injuries can lead to persistent instability, which may result in the failure of meniscal repairs, cruciate reconstructions, and damage to the articular cartilage.15,16 Therefore, accurate diagnosis and management of medial knee injuries are critical.
Accurate and timely diagnosis of MCL injuries is essential for effective management and optimal return to function. Physical examination is the first step in diagnosing MCL injuries, but its reliability can be affected by factors such as the examiner’s expertise, patient tolerance, and the presence of other injuries. Consequently, advanced imaging techniques are frequently employed to confirm the diagnosis and assess the extent of the injury. Stress radiography is a common diagnostic tool used to assess MCL injuries. It allows for the quantification of medial joint space opening under valgus stress, providing valuable information for therapeutic decision-making. However, stress radiography involves radiation exposure and necessitates multiple images to ensure proper femoral and tibial rotation. In addition to stress radiography, magnetic resonance imaging (MRI) is widely used for assessing knee ligament injuries and is considered the gold standard. However, MRI has limitations, including its high cost, limited availability, and inability to provide real-time functional assessment of the ligaments. Additionally, MRI is not suitable for patients with metal implants, pacemakers, or claustrophobia.
Musculoskeletal ultrasonography (MSK-US) is gaining recognition as a reliable and cost-effective method for assessing knee ligament injuries, including those of the MCL. MSK-US offers dynamic, real-time imaging that can be performed in an office setting without the need for radiation. Stress can be applied during the examination to evaluate the opening of both the medial and lateral tibiofemoral compartments. Functional MSK-US is now being used as a diagnostic tool to enhance postoperative radiological outcome measurements. Recently, mean values of medial joint space width in unloaded and standardized loaded conditions using a fixation device have been published.17 Studies have shown that MSK-US is a reliable and accurate tool for assessing medial knee injuries, with comparable results to MRI.13,14 Despite these advantages, MSK-US is not yet a standard modality for assessing MCL injuries, with stress radiography and MRI being more commonly used. However, the increasing use of ulstraound (US) in musculoskeletal conditions highlights its potential as a valuable diagnostic tool, particularly given its portability, low cost, and ability to visualize and compare healthy and injured structures under applied stress.
Advantages of Musculoskeletal Ultrasound
MSK-US employs high-frequency sound waves to produce images of soft tissues, joints, and bones. The principal advantages include real-time imaging capabilities, absence of ionizing radiation, and the ability to conduct comparative assessments of the affected and contralateral sides. Furthermore, its portability and lower cost relative to MRI make it accessible in various clinical settings.
Ultrasound Technique and Diagnostic Criteria for MCL Injuries
MSK-US is highly effective in identifying the presence and severity of MCL injuries. The ligament’s superficial location makes it readily accessible for US examination, which can be enhanced with high-frequency linear transducers to produce detailed soft-tissue images. Dynamic imaging during knee flexion and extension, not possible with MRI, further improves the diagnostic accuracy of US by demonstrating the static functional integrity of the MCL. The examination involves scanning in both longitudinal and transverse orientations, assessing the ligament for echotexture, continuity, and any associated anechoic (fluid) collections indicating acute injury. Diagnostic criteria for MCL injuries are based on ligament thickness, loss of the normal fibrillar pattern, and the presence of preligamentous fluid. One tip when assessing the femoral insertion of the superficial fibers of the MCL is gently tilt the probe along the MCL curved course to avoid the anisotropic effect of a false hypoechogenicity.18
Clinical Implications
Diagnostic MSK-US offers the ability to visualize these pathological changes in real-time and provides immediate feedback that can inform treatment decisions. Rehabilitation providers can use this information to tailor exercise programs, guide manual therapy techniques, monitor the progression of ligament healing over time, or refer to another provider in instances of tears or ruptures that may require further imaging or surgical intervention. Additionally, ultrasound-guided interventions, such as injections, can be performed with greater accuracy and safety.
Limitations of Musculoskeletal Ultrasound
While MSK-US offers several advantages, including patient comfort and dynamic assessment capabilities, it also has limitations. Operator dependency, a steep learning curve, and variability in image interpretation are notable challenges. Therefore, comprehensive training and experience are essential for maximizing the diagnostic utility of this modality.
Conclusion
MSK-US is an effective and efficient tool for diagnosing MCL injuries of the knee. Its ability to provide immediate, detailed insights into soft tissue integrity makes it an invaluable component of the diagnostic and rehabilitation process. Ongoing training and standardization of ultrasound techniques among rehabilitation providers will be essential to fully realize the potential of MSK-US in clinical practice.
Figure 1. Patient Position.

Figure 1A: Patient Position: Patient is supine with a bolster under the knee to provide 30 degrees of knee flexion. This position places the quadriceps on slack. The foot and leg are externally rotated to expose the medial aspect of the knee. To provide a more dynamic assessment of the MCL, a colleague can apply a valgus stress to the knee to increase the strain on the MCL (not shown).
Figure 1B: Long Axis Transducer Placement: The transducer is placed in a long axis orientation (LAX) on the posterior margin of the medial knee, and then translated /skimmed anteriorly into a sonographic window (as shown in Figure 1B) that best visualizes the accessible portion of the meniscus and adjacent MCL.
Figure 2. Normal View in Long Axis (LAX):

Figures 2A and 2B Long Axis View: The MCL is a flat, band-like ligament approximately 9 cm long, extending from the femoral epicondyle to the antero-medial tibia. It is essential to examine the entire length of the MCL. Sweep the transducer from proximal to distal and from posterior to anterior. The MCL widens as it crosses the joint space and consists of anterior and posterior bands. Branches of the geniculate artery system pierce the posterior band of the MCL, which can be mistaken for tears. These vessels are pulsatile in real-time and can be viewed with a power doppler setting (not shown).
Figure 3. Distal MCL Avulsion Fracture and Sprain.

Figures 3A and 3B: These figures show an MCL sprain of the right knee. Figure 3A shows a calcification or avulsion fracture shown at the distal end of the MCL with the white arrow. Figure 3B shows fluid and hematoma in the deep fibers of the MCL as noted with the yellow arrow, and the white arrow in Figure 3B shows the disruption of the MCL fibers indicating a sprain.
Figure 4. MCL Sprain.

Figures 4A: A hypoechoic interruption (white arrow) in the proximal meniscofemoral ligament represents a tear in the deep portion of the MCL.
References
- Review: Medial collateral ligament injuries. Andrews K., Lu A., Mckean L., Ebraheim N. 2017J Orthop. 14(4):550–554. doi: 10.1016/j.jor.2017.07.017. doi: 10.1016/j.jor.2017.07.017. [DOI] [PMC free article] [PubMed] [Google Scholar]
- The medial collateral ligament: the neglected ligament. Williams A., Becker R., Amis A. 2020Knee Surg Sports Traumatol Arthrosc. 28(12):3698–3699. doi: 10.1007/s00167-020-06116-z. doi: 10.1007/s00167-020-06116-z. [DOI] [PubMed] [Google Scholar]
- Surgical Techniques for the Reconstruction of Medial Collateral Ligament and Posteromedial Corner Injuries of the Knee: A Systematic Review. DeLong J.M., Waterman B.R. 2015Arthrosc J Arthrosc Relat Surg. 31(11):2258–2272.e1. doi: 10.1016/j.arthro.2015.05.011. doi: 10.1016/j.arthro.2015.05.011. [DOI] [PubMed] [Google Scholar]
- Medial collateral ligament of the knee: anatomy, management and surgical techniques for reconstruction. Memarzadeh A., Melton J.Tk. 2019Orthop Trauma. 33(2):91–99. doi: 10.1016/j.mporth.2019.01.004. doi: 10.1016/j.mporth.2019.01.004. [DOI] [Google Scholar]
- Medial collateral ligament reconstruction is necessary to restore anterior stability with anterior cruciate and medial collateral ligament injury. Zhu J., Dong J., Marshall B., Linde M. A., Smolinski P., Fu F. H. 2018Knee Surg Sports Traumatol Arthrosc. 26(2):550–557. doi: 10.1007/s00167-017-4575-x. [DOI] [PubMed] [Google Scholar]
- Current concepts on management of medial and posteromedial knee injuries. Madi S., Acharya K., Pandey V. 2022J Clin Orthop Trauma. 27:101807. doi: 10.1016/j.jcot.2022.101807. doi: 10.1016/j.jcot.2022.101807. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Magnetic resonance imaging of medial collateral ligament avulsion fractures of the knee in children: a potentially underestimated injury. Jarrett D.Y., Kramer D.E., Laor T. 2021Pediatr Radiol. 51(9):1705–1713. doi: 10.1007/s00247-021-05040-9. doi: 10.1007/s00247-021-05040-9. [DOI] [PubMed] [Google Scholar]
- The role of the medial collateral ligament and posteromedial capsule in controlling knee laxity. Robinson J. R., Bull A. M. J., Thomas R. R. D., Amis A. A. 2006Am J Sports Med. 34(11):1815–1823. doi: 10.1177/0363546506289433. doi: 10.1177/0363546506289433. [DOI] [PubMed] [Google Scholar]
- The Medial and Posteromedial Ligamentous and Capsular Structures of the Knee: Review of Anatomy and Relevant Imaging Findings. Pedersen R. R. 2016Semin Musculoskelet Radiol. 20(1):12–25. doi: 10.1055/s-0036-1579710. doi: 10.1055/s-0036-1579710. [DOI] [PubMed] [Google Scholar]
- Treatment of medial-sided injuries in patients with early bicruciate ligament reconstruction for knee dislocation. Jokela M. A., Mäkinen T. J., Koivikko M. P., Lindahl J. M., Halinen J., Lindahl J. 2021Knee Surg Sports Traumatol Arthrosc. 29(6):1872–1879. doi: 10.1007/s00167-020-06207-x. doi: 10.1007/s00167-020-06207-x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Medial Collateral Ligament Injury of the Knee: A Review on Current Concept and Management. Vosoughi F., Rezaei Dogahe R., Nuri A., Ayati Firoozabadi M., Mortazavi J. 2021Arch Bone Jt Surg. 9(3):255–262. doi: 10.22038/abjs.2021.48458.2401. doi: 10.22038/abjs.2021.48458.2401. [DOI] [PMC free article] [PubMed] [Google Scholar]
- The non-surgical management of isolated medial collateral ligament injuries of the knee. Giannotti B.F., Rudy T., Graziano J. 2006Sports Med Arthrosc Rev. 14(2):74–77. doi: 10.1097/01.jsa.0000212307.54947.e4. doi: 10.1097/01.jsa.0000212307.54947.e4. [DOI] [PubMed] [Google Scholar]
- Midterm Outcomes, Complications, and Return to Sports After Medial Collateral Ligament and Posterior Oblique Ligament Reconstruction for Medial Knee Instability: A Systematic Review. D’Ambrosi R., Corona K., Guerra G.., et al. 2021Orthop J Sports Med. 9(11):23259671211056070. doi: 10.1177/23259671211056070. doi: 10.1177/23259671211056070. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Anatomic medial knee reconstruction restores stability and function at minimum 2 years follow-up. Tapasvi S., Shekhar A., Patil S., Getgood A. 2022Knee Surg Sports Traumatol Arthrosc. 30(1):280–287. doi: 10.1007/s00167-021-06502-1. [DOI] [PubMed] [Google Scholar]
- Does ACL reconstruction restore knee stability in combined lesions?: An in vivo study. Zaffagnini S., Bignozzi S., Martelli S., Lopomo N., Marcacci M. 2007Clin Orthop. 454:95–99. doi: 10.1097/BLO.0b013e31802b4a86. doi: 10.1097/BLO.0b013e31802b4a86. [DOI] [PubMed] [Google Scholar]
- Treatment of Combined Injuries to the ACL and the MCL Complex: A Consensus Statement of the Ligament Injury Committee of the German Knee Society (DKG) Guenther D., Pfeiffer T., Petersen W.., et al. 2021Orthop J Sports Med. 9(11):23259671211050929. doi: 10.1177/23259671211050929. doi: 10.1177/23259671211050929. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ultrasound-based examination of the medial ligament complex shows gender- and age-related differences in laxity. Lutz P. M., Feucht M. J., Wechselberger J.., et al. 2021Knee Surg Sports Traumatol Arthrosc. 29(6):1960–1967. doi: 10.1007/s00167-020-06293-x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Artifacts in Musculoskeletal Ultrasonography: From Physics to Clinics. Wu W. T., Chang K. V., Hsu Y. C., Hsu P. C., Ricci V., Özçakar L. 2020Diagn Basel Switz. 10(9):645. doi: 10.3390/diagnostics10090645. doi: 10.3390/diagnostics10090645. [DOI] [PMC free article] [PubMed] [Google Scholar]
