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. 2024 Sep 6;15:7722. doi: 10.1038/s41467-024-52107-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 2 — a Sectional view displaying the electrostatic surface of Cdr1^Flu. Red-colored fluconazole resides at the top of the hydrophobic central cavity. b Side (left figure) and bottom (right figure) views of Cdr1^Flu. Fluconazole is surrounded by TM1b, TM2a and TM5a from TMD1(sky-blue), TM8 and TM11a from TMD2 (orange). c Coordination of fluconazole by TMDs of Cdr1^Flu. Residues from TMD1 are colored by sky-blue, while those from TMD2 are colored by orange. Magenta dashes indicate hydrogen bonds. d Relative OD_600nm values for wild type and mutants under a 10 µg/mL fluconazole concentration. The y-axis represents the relative OD_600nm values as a percentage of the control (no drug). Three independent experiments were conducted for both wild type and mutants. Data are presented as mean values ± SD; n = 3 independent experiments.