Table 2.
Topological analysis of the core targets.
| Gene | Betweenness | Closeness | Degree |
|---|---|---|---|
| TP53 | 865.0016346 | 0.5436893 | 20 |
| STAT3 | 147.1061907 | 0.4590164 | 9 |
| SRC | 247.9310858 | 0.4375 | 13 |
| SIRT1 | 359.7111989 | 0.4444444 | 8 |
| RELA | 466.2387138 | 0.5137615 | 14 |
| PIK3CA | 185.9385613 | 0.4210526 | 7 |
| MTOR | 283.2259574 | 0.3943662 | 9 |
| MAPK8 | 78.08196023 | 0.4444444 | 9 |
| MAPK3 | 58.0740529 | 0.4341085 | 9 |
| MAPK1 | 90.56457153 | 0.4444444 | 11 |
| KRAS | 118.0997267 | 0.4028777 | 8 |
| JUN | 154.5255859 | 0.4827586 | 14 |
| IL6 | 153.3786971 | 0.4210526 | 9 |
| IL1B | 67.20881341 | 0.4028777 | 7 |
| HRAS | 52.78975995 | 0.4117647 | 9 |
| HIF1A | 91.0314127 | 0.4375 | 9 |
| EGFR | 161.5513198 | 0.4179104 | 11 |
| CREB1 | 119.9051715 | 0.4242424 | 8 |