Table 1.

Comprehensive list of CD47 associated/interacted proteins and their major functions.

CD47 interacting proteins			Biological functions	References
Extracellular	TSP-1 (C-terminal domain)		apoptosis, inhibition of angiogenesis, immunosuppressive, promoting ROS production, and inflammatory response	[37]
	SIRPα		inhibition of phagocytosis, adhesion and migration, dendritic cell function and T Cell activation.	[60]
	SIRPγ		T-cell proliferation and T-cell trans-endothelial migration.	[61], [62]
	Serpin A1 (C-terminal)		proliferation stimulation	[63]
	COMP		inflammation and joint destruction in osteoarthritis	[64]
Membrane	Integrin	αvβ3	human melanoma cells spreading (C32), binding to vitronectin, PMN activation, calcium regulation, and proinflammatory cytokine synthesis	[65]
		αIIbβ3	platelet activation	[66], [67],
		α2β1	chemotactic response of smooth muscle cells	[68]
		α4β1	T cell antigen receptor antagonist, anti-proliferative activities and T cell adhesion, and B-cell migration	[69]
		α5β1	chondrocyte mechano-transduction	[70]
		α6β1	microglial activation	[71]
		αMβ2	neutrophil transepithelial migration	[72]
	VEGFR-2		immunosuppressive activity of VEGF in T cells, inhibition of VEGFR2activation	[73], [74]
	CD36		inhibition of NO-stimulated phenotypic responses and cGMP signaling in vascular cells	[75], [76]
	Fas/CD95		activation of Fas (CD95) mediates apoptosis	[77]
Intracellular	PLIC-1		inducing redistribution of vimentin and cell spreading, and inhibition of Gi signaling	[78], [79]
	BNIP3		T Cell apoptosis	[80]
	ERK		inhibiting smooth muscle cell migration	[81]
	Syk		phosphorylation of Lyn, Syk and FAK	[66]
	Gαs, Gαq and Gβγ		stimulating astrocytoma proliferation via Akt	[82]
	RAC		neurite and filopodium formation	[33]
	CDC42		neurite and filopodium formation	[33], [83]
	Src		dendritic development	[83]
	PI3K		cell spreading	[84]
	ENO1		enhancing aerobic glycolysis	[85]
	Drp1		caspase-Independent Cell Death	[86]