Table 2.
MiRNAs regulate CD47 expression.
| miRNA name | Mechanism and function | Resource |
|---|---|---|
| miR-708 | miR-708 directly binds the 3′-UTR of CD47 and inhibits CD47 in T cells acute lymphoblastic leukemia. | [110] |
| miR-155 | miR-155 downregulates CD47 in myeloma cells and increases phagocytosis of cancer cells by macrophages and inhibits tumor growth in mice. | [111] |
| miR-192 | miR-192 binds the 3′-UTR of CD47 and suppresses CD47 at the post-transcriptional level in medulloblastoma. | [112] |
| miR-133a | miR-133a binds to the 3′-UTR of CD47 directly and suppresses its protein expression in esophageal squamous cell carcinoma and laryngeal carcinoma. | [113], [114] |
| miR-200a | miR-200a affects NPC cell growth and invasion by regulating CD47 in Nasopharyngeal carcinoma. | [115] |
| miR-222 | miR-222 directly decreases CD47 expression in human kidney carcinoma cells. | [116] |
| miR-340 | miR-340 down-regulates the expression of CD47 in pancreatic cancer cells. | [117] |
| miR-34a | miR-34a targets the 3′UTR of CD47/PD-L1. | [118], [119] |
| miR-326 | miR-326 is upregulated in multiple sclerosis (MS) and inhibits CD47 by targeting 3′UTR CD47. | [120] |
| miR-141 | miR-141 has a negative regulatory effect on CD47 and cullin 3 by binding to the 3′UTR of CD47 and CUL3. | [121] |
| miR-378a | miR-378a regulates macrophage phagocytosis and differentiation by blocking the CD47-SIRPα pathway in atherosclerosis. | [122] |
| miR-149 | LncRNA MIAT sponges miR-149-5p to suppress phagocytosis via upregulating CD47 in advanced atherosclerosis. | [123] |
| miR-423-5p | In 92.1 UM cell lines, transfection with miR-423-5p down-regulates CD47 expression. | [124], [125] |
| miR-17/20a/106a | Inhibition of miR-1720a/106a in mouse peritoneal macrophage upregulates SIRPα at the post-transcriptional level and reduction of phagocytosis. | [126] |
| miR-7 | miR-7 downregulates EGFR mRNA by binding to its 3′ UTR, and the expression of EGFR promotes CD47 expression. | [127] |
| Let-7i-5p | Targeting TSP-1 in HCC, TSP-1 competes with SIRPα to bind to CD47 to prevent anti-apoptotic and angiogenesis signal transduction between macrophage cells and HCCs. | [128], [129] |