Table 4.
Association of detected variants with COVID-19 severity.
| Model | Genotype | Non-hospitalized | Hospitalized | Odd ratio (95% CI) | p-value |
|---|---|---|---|---|---|
| IL-12A rs2243136 | |||||
| Codominant | T/T | 82 (81.2%) | 85 (80.2%) | 1.00 | 0.29 |
| T/C | 19 (18.8%) | 19 (17.9%) | 0.96 (0.48-1.95) | ||
| C/C | 0 (0%) | 2 (1.9%) | NA (0.00-NA) | ||
| Dominant | T/T | 82 (81.2%) | 85 (80.2%) | 1.00 | 0.89 |
| T/C-C/C | 19 (18.8%) | 21 (19.8%) | 1.07 (0.53-2.13) | ||
| Recessive | T/T-C/C | 101 (100%) | 0 (0%) | 1.00 | 0.10 |
| C/C | 0 (0%) | 2 (1.9%) | NA (0.00-NA) | ||
| IL-12A rs35990253 | |||||
| Codominant | G/G | 89 (88.1%) | 98 (92.5%) | 1.00 | 0.34 |
| G/A | 11 (10.9%) | 8 (7.5%) | 0.66 (0.25-1.72) | ||
| A/A | 1 (1%) | 0 (0%) | 0.00 (0.00-NA) | ||
| Dominant | G/G | 89 (88.1%) | 98 (92.5%) | 1.00 | 0.29 |
| G/A-A/A | 12 (11.9%) | 8 (7.5%) | 0.61 (0.24-1.55) | ||
| Recessive | G/G-G/A | 100 (99%) | 106 (100%) | 1.00 | 0.23 |
| A/A | 1 (1%) | 0 (0%) | 0.00 (0.00-NA) | ||
| IL-12B rs11574790 | |||||
| Codominant | G/G | 70 (69.3%) | 67 (63.2%) | 1.00 | 0.61 |
| G/A | 27 (26.7%) | 35 (33%) | 1.35 (0.74-2.48) | ||
| A/A | 4 (4%) | 4 (3.8%) | 1.04 (0.25-4.35) | ||
| Dominant | G/G | 70 (69.3%) | 67 (63.2%) | 1.00 | 0.35 |
| G/A-A/A | 31 (30.7%) | 39 (36.8%) | 1.31 (0.74-2.34) | ||
| Recessive | G/G-G/A | 97 (96%) | 102 (96.2%) | 1.00 | 0.94 |
| A/A | 4 (4%) | 4 (3.8%) | 0.95 (0.23-3.91) | ||
| IL-12B rs3212227 | |||||
| Codominant | T/T | 53 (52.5%) | 56 (52.8%) | 1.00 | 0.83 |
| T/G | 37 (36.6%) | 41 (38.7%) | 1.05 (0.59-1.88) | ||
| G/G | 11 (10.9%) | 9 (8.5%) | 0.77 (0.30-2.02) | ||
| Dominant | T/T | 53 (52.5%) | 56 (52.8%) | 1.00 | 0.96 |
| T/G-G/G | 48 (47.5%) | 50 (47.2%) | 0.99 (0.57-1.70) | ||
| Recessive | T/T-T/G | 90 (89.1%) | 97 (91.5%) | 1.00 | 0.56 |
| G/G | 11 (10.9%) | 9 (8.5%) | 0.76 (0.30-1.92) | ||
| IL-12B rs919766 | |||||
| Codominant | A/A | 68 (67.3%) | 68 (64.2%) | 1.00 | 0.71 |
| A/C | 31 (30.7%) | 34 (32.1%) | 1.10 (0.61-1.98) | ||
| C/C | 2 (2%) | 4 (3.8%) | 2.00 (0.35-11.29) | ||
| Dominant | A/A | 68 (67.3%) | 68 (64.2%) | 1.00 | 0.63 |
| A/C-C/C | 33 (32.7%) | 38 (35.9%) | 1.15 (0.65-2.05) | ||
| Recessive | A/A-A/C | 99 (98%) | 102 (96.2%) | 1.00 | 0.44 |
| C/C | 2 (2%) | 4 (3.8%) | 1.94 (0.35-10.84) | ||
| IL-6 rs2069840 | |||||
| Codominant | C/C | 66 (65.3%) | 69 (65.1%) | 1.00 | 0.54 |
| C/G | 32 (31.7%) | 36 (34%) | 1.08 (0.60-1.93) | ||
| G/G | 3 (3%) | 1 (0.9%) | 0.32 (0.03-3.14) | ||
| Dominant | C/C | 66 (65.3%) | 69 (65.1%) | 1.00 | 0.97 |
| C/G-G/G | 35 (34.6%) | 37 (34.9%) | 1.01 (0.57-1.79) | ||
| Recessive | C/C-C/G | 98 (97%) | 105 (99.1%) | 1.00 | 0.28 |
| G/G | 3 (3%) | 1 (0.9%) | 0.31 (0.03-3.04) | ||
| TNF rs3093662 | |||||
| Alleles | A | 185 (92%) | 188 (89%) | 1.00 | 0.34 |
| G | 17 (8%) | 24 (11%) | 1.38 (0.72-2.60) | ||
| Codominant | A/A | 84 (83.2%) | 82 (77.4%) | 1.00 | 0.29 |
| A/G | 17 (16.8%) | 24 (22.6%) | 1.45 (0.72-2.89) | ||