Table 2.

Clinical and pathological characteristics of patients with breast cancer depending on the status of hypermethylation of the BRCA2 gene promoter region

Clinical and pathological	BC, blood samples ($n=$ 74)		BC, tumour samples ($n=$74)
characteristics	MU	UU	MU	UU
Number of samples	12	62	31	43
Age, years	56.9 $\pm$ 12.8	51.7 $\pm$ 14.3	55.0 $\pm$ 14.0	50.7 $\pm$ 14.1
$p$ value	0.15		0.11
Age groups
Up to 50 years	3 (25.0%)	36 (58.1%)	10 (32.3%)	24 (55.8%)
After 50 years	9 (75.0%)	26 (41.9%)	21 (67.7%)	19 (44.2%)
$p$ value	0.07		0.045
Diagnosis
Bilateral	0 (0.0%)	4 (6.5%)	2 (6.5%)	2 (4.7%)
Dex	7 (58.3%)	23 (37.1%)	14 (45.2%)	16 (37.2%)
Sin	5 (41.7%)	35 (56.5%)	15 (48.4%)	25 (58.1%)
$p$ value	0.32		0.70
Stage
I $+$ II	8 (66.7%)	47 (75.8%)	21 (67.7%)	34 (79.1%)
III $+$ IV	4 (33.3%)	15 (24.2%)	10 (32.3%)	9 (20.9%)
$p$ value	0.51		0.27
Histological type
Ductal	10 (83.3%)	52 (83.9%)	27 (87.1%)	35 (81.4%)
Others	2 (16.7%)	10 (16.1%)	4 (12.9%)	8 (18.6%)
$p$ value	0.96		0.51
Estrogen receptor
Positive	9 (75.0%)	48 (77.4%)	21 (67.7%)	36 (83.7%)
Negative	3 (25.0%)	14 (22.6%)	10 (32.3%)	7 (16.3%)
$p$ value	0.86		0.11
Progesterone receptor
Positive	6 (50.0%)	46 (74.2%)	18 (58.1%)	34 (79.1%)
Negative	6 (50.0%)	16 (25.8%)	13 (41.9%)	9 (20.9%)
$p$ value	0.09		0.051
HER2/neu
Positive	1 (8.3%)	10 (16.1%)	5 (16.1%)	6 (14.0%)
Negative	11 (91.7%)	52 (83.9%)	26 (83.9%)	37 (86.0%)
$p$ value	0.49		0.80
Ki67, %	31.4 $\pm$ 11.2	30.7 $\pm$ 15.2	33.7 $\pm$ 13.0	28.9 $\pm$ 15.2
$p$ value	0.76		0.18
Ki67 groups
Low (0%–15%)	1 (8.3%)	10 (19.2%)	1 (3.8%)	10 (26.3%)
Intermediate (16%–29%)	7 (58.3%)	19 (36.5%)	13 (50.0%)	13 (34.2%)
High ($⩾$ 30%)	4 (33.3%)	23 (44.2%)	12 (46.2%)	15 (39.5%)
$p$ value	0.35		0.045
Molecular subtype
TNBC	3 (25.0%)	12 (19.4%)	9 (29.0%)	6 (14.0%)
Luminal A	6 (50.0%)	25 (40.35)	11 (35.5%)	20 (46.5%)
Luminal B	3 (25.0%)	23 (37.1%)	10 (32.3%)	16 (37.2%)
HER2-positive	0 (0.0%)	2 (3.2%)	1 (3.2%)	1 (2.3%)
$p$ value*	0.76		0.44
Family history
Positive	5 (41.7%)	31 (50.0%)	15 (48.4%)	21 (48.8%)
Negative	7 (58.3%)	31 (50.0%)	16 (51.6%)	22 (51.2%)
$p$ value	0.60		0.97

M – methylated; U – unmethylated.